NEXT GENERATION SEQUENCING
(NGS) SERVICES


TARGETED RESEQUENCING, WHOLE GENOME/EXOME,
DE NOVO SEQUENCING AND GENOME WIDE ASSOCIATION STUDIES (GWAS)


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Exome
Sequencing 80x

Illumina Omni
Express (GWAS)

Human mtDNA
Sequencing

Whole Genome
Sequencing

THE SIMPLE CHOICE...

NEXT GENERATION

DATA SEQUENCING AT FULL COVERAGE


DNA DTC offers a wide range of Research Use Only (RUO) tests utilizing next generation sequencing including the entire exome (at 80x coverage) and the whole genome.

EFFICIENCY DEFINED

SPEED, RELIABILITY, COST IN ONE


DNA DTC's state-of-the-art automated laboratory and ultra-efficient processes allow us to deliver highly reliable genomic testing at reasonable prices with excellent processing times.

EVOLUTION OF TESTING

THE NAME IN DNA YOU CAN TRUST


DNA DTC is the RUO division of Gene by Gene and a sister division to Family Tree DNA which pioneered the concept of direct to consumer DNA tests in the field of genetic genealogy in 2000.


SETTING THE STANDARD IN GENETIC SEQUENCING

ADVANCED TECHNOLOGY

DELIVERING INDUSTRY LEADING RESULTS
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OUR PRODUCTS


EXOME SEQUENCING

AVERAGE 80X COVERAGE


The exome contains the functionally important coding regions of the human genome. Exome sequencing selectively targets these portions of the genome and has proven to be efficient and extremely cost-effective method of identifying DNA variants.


In contrast to traditional Sanger sequencing tests that analyze a single gene or small groups of genes at once, exome sequencing has the ability to simultaneously analyze approximately 60 million base pairs, representing 22,000 genes using next-generation sequencing (NGS). Sequencing of the exome can help identify variants that may be the genetic cause of a wide range of traits and conditions. NGS relies on a method that enriches a sample by using DNA capture probes targeted only to the exome portion of the genome. Please note that as a Research Use Only test, the exome does not include any analysis or interpretation.
The technique enriches a sample using a DNA capture method targeted only to the exome portion of the genome.

Illumina Sequence
DNA DTC’s exome sequencing service utilizes the Illumina HiSeq platform and has an average coverage of 80X, allowing for a high degree of accuracy in identifying variants in an individual’s DNA.


Since DNA DTC provides Research Use Only tests, we disclose the variants that have been identified, however no analysis or interpretation will be provided.
DNA DTC uses the Illumina HiSeq platform for exome testing. For additional technical details, please click here.


Price: $895.00

Average turnaround: 8-10 weeks


Place an Order

 

ILLUMINA OMNI EXPRESS –
FOR GENOME WIDE ASSOCIATION STUDIES (GWAS)

Optimized tag SNP content from all three HapMap phases has been strategically selected to capture the greatest amount of common variation and drive the discovery of novel associations with traits and conditions.


 

The Illumina Omni Express array is a 12-sample BeadChip belonging to the Next-Gen GWAS Omni family of microarrays designed to provide high sample throughput and comprehensive genomic content. It includes a total of 730,525 genome-wide markers with an average spacing of 4Kb and targets a minor allele frequency of 5% as reported in the HapMap data. This includes SNPs with 10kb of RefSeq genes, nonsynonymous SNPs (NCBI annotated), MHC/ADME SNPs, and sex chromosomes.

Coupled with the Illumina iScan platform, this Industry-standard Assay affords greater than 99% average call rates and greater than 99.9% reproducibility. The Omni Express array also supports copy number variation (CNV) analyses.

Price: $199.00

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HUMAN MITOCHONDRIAL DNA SEQUENCING

>2000X coverage utilizing the Illumina MiSeq Platform


The DNA sequence of mtDNA has been determined from a very large number of individuals, and the comparison of those DNA sequences represents a mainstay of phylogenetics, in that it allows biologists to elucidate the evolutionary relationships among species. It also permits an examination of the relatedness of populations, and so has become important in anthropology and field biology.


This is the highest level mtDNA test possible. Testing covers all 16,569 base pairs which includes HVR1 and HVR2 (Hypervariable regions 1 and 2, also called the control region) and the Coding Region.

Illumina Sequence Image Credited to Bioscience.org
DNA DTC sequences the the mtDNA genome at an average coverage of 2000x, allowing for a high degree of accuracy in identifying all variations including heteroplasmies.


The standard limit of detection for heteroplasmies is 20%. However, for some applications this may be too low or too high. At a customer’s request, we can customize the heteroplasmy detection limit, allowing further flexibility in designing a product specifically tailored to meeting your research needs.


$495.00

Average turnaround: 8-10 weeks


Place an Order

WHOLE GENOME SEQUENCING

AVERAGE 30X COVERAGE


DNA DTC’s whole genome sequencing service utilizes the Illumina HiSeq platform and has an average coverage of 30X, allowing for a high degree of accuracy in identifying novel variants in an individual’s DNA.

While exome sequencing focuses on the detection of genomic variants in coding regions of the genome, whole genome sequencing also includes non-coding regions and allows a more complete view of an individual’s genetic makeup. DNA DTC provides sample preparation, QC and sequencing. Customers are provided with their raw data as a fast queue file. Please note that as a Research Use Only test, the whole genome does not include any analysis or interpretation.

Whether using the high throughput mode of the HiSeq 2000 or the rapid run mode of the HiSeq 2500, DNA DTC can offer experimental flexibility for a wide range of research needs, while providing Industry leading data quality and a cost effective workflow.

Price: $6,995.00

Place an Order


OUR TEAM


The People Behind
DNA DTC

Doron Behar, M.D., Ph.D, - Chief Scientist

Dr. Behar received his degrees from the Technion - Israel Institute of Technology. As an M.D. he has dual specialization in Internal Medicine and Critical Care Medicine in Rambam Medical Center, Haifa Israel. His Ph.D thesis was in the field of Population Genetics. Dr. Behar's research areas of interest are across the broad range of evolutionary genomics, ancestry, phylogenetics and translational genomics -- having been the leading author and co-author of numerous research papers in these areas. His current primary interest is developing robust, low-priced genetic testing for the general public that will allow responsible personalized genetic medicine to any individual worldwide.

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Prof. Motti Shohat, M.D., - Medical Advisor

Dr. Shohat is a world renowned expert in medical genetics with 248 original research articles to his credit. He has co-authored and edited two books, and received numerous personal awards for his achievements in genetics research. For several decades he has served as professor of pediatrics and medical genetics at Tel Aviv University and Director of the Rafael Recanathi institute for Medical Genetics. Dr. Shohat is a member of the Israeli, American and European Societies of Medical Genetics, as well as of the National Counseling Committee of the Ministry of Health for OB/GYN and Genetics.

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Connie Bormans, Ph.D. - Laboratory Director

Dr. Bormans received her Ph.D. in genetics from Texas A&M University where she developed new STR marker panels for use in plant breeding. As a Research Fellow at the University of Texas Health Science Center at Houston, she managed three large scale projects to identify genes related to cardiovascular disease.

She is currently focused on developing efficient methods for large scale genotyping projects using both direct sequencing and STR analysis.

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Michael Bauer, M.D. - CLIA Lab Director

Dr. Bauer began work in Clinical Pathology at Loma Linda University Medical Center and went on to complete a fellowship in Transfusion Medicine at Cedars-Sinai Medical Center. During this training, he gained valuable experience in clinical laboratory testing and laboratory administration. Dr. Bauer has been a consulting physician since 1994 and is certified in Clinical Pathology, Blood Banking and Transfusion Medicine, as well as being a Tissue Banking specialist. Dr. Bauer currently acts as CLIA Lab Director for Gene by Gene.

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Ruth Katz, M.D. - Advisory Board

Dr. Katz is a board certified Anatomic Pathologist and Cytopathologist who is currently Professor of Pathology, Chief Research Cytopathology, and Director, Image Cytometry Diagnostic Laboratory at the University of Texas M.D. Anderson Cancer Center, Houston, Texas.

Dr. Katz received her medical degree from the University of Witwatersrand Medical School in Johannesburg, South Africa. She completed a residency in anatomic pathology and hematopathology at the University of Cape Town, South Africa, along with a residency in anatomic pathology at New England Medical Center Tufts Hospital in Boston, Massachusetts. She served fellowships in Laboratory Medicine and Cytopathology at The University of Texas M.D. Anderson Cancer Center, Houston,Texas. Dr. Katz was Chief of Cytopathology at University of Texas M.D. Anderson Cancer Center from 1984 until 1998. During that time she was instrumental in setting up the Quality Assurance and Quality Control Program for Cytopathology, including gynecological cytopathology. She also instituted the regulations as required by the CLIA Act of 1988, and has been actively involved in cervical cytology quality assurance for over 20 years.

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Spencer Wells, Ph.D. - Advisory Board

Spencer Wells is an Explorer-in-Residence at the National Geographic Society and Frank H. T. Rhodes Class of 1956 Professor at Cornell University. He leads The Genographic Project, which is collecting and analyzing hundreds of thousands of DNA samples from people around the world in order to decipher how our ancestors populated the planet.

Wells received his Ph.D. in population genetics from Harvard University and conducted postdoctoral work at Stanford and Oxford. He has appeared in numerous documentary films and is the author of three books, The Journey of Man, Deep Ancestry and Pandora's Seed.

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Eran Halperin, Ph.D. - Advisory Board

Eran Halperin is a senior research scientist in the International Computer Science Institute (ICSI) in Berkeley, California and an associate professor in Tel-Aviv University in the School of Computer Science and in the Department of Microbiology. His research group works on computational methods for the analysis of population genetics data. His group has developed methods that have been used by thousands of researchers worldwide in order to understand the genetic causes of diseases such as cardiovascular diseases and cancer.
Professor Halperin has published more than 80 peer-reviewed articles across different disciplines including human and population genetics, computational biology, algorithms, and operations research. He received various honors for academic achievements, including the Rothschild Fellowship, the Intel, and the Krill prizes. Professor Halperin received his Ph.D. in computer science from Tel-Aviv University.

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Max Blankfeld, Managing Partner

With an academic background spanning from Aeronautical Engineering to Political Sciences, Max Blankfeld found his true vocation after graduating summa cum laude with a BBA from Fundação Getulio Vargas in Brazil. After moving to Houston, Texas in 1991, he completed his MBA at Rice University, majoring in Finance, Marketing and Entrepreneurship.

Before coming to the United States, Blankfeld held top management positions at publicly traded companies, where he was responsible for operations and growth strategies. During his years in the US, he started and managed a company in the area of consumer products, until he sold it in 2001.

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Bennett Greenspan, Managing Partner

An entrepreneur and life-long genealogy enthusiast, Mr. Greenspan founded Family Tree DNA in 2000, the original unit of what went to become Gene by Gene. Prior business and entrepreneur experience spans photo-imaging/industrial photography and commercial Real Estate. In a prior career Mr. Greenspan oversaw the conversion of a company sales force from analog to digital data capture..


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CONTACT US


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